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Orphan Receptor Antibodies

The sequencing of the human genome has allowed NC-IUPHAR to catalog all of the human gene sequences potentially encoding GPCRs, excluding sensory receptors. In addition to established transmitter systems, the classification in the Guide to PHARMACOLOGY also includes ‘orphan’ GPCRs where the endogenous ligand(s) is not known. Considerable progress has been made in screening artificially expressed receptors to identify the cognate endogenous ligand.

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Validation of the GPR15 Receptor in transfected HEK293 cells
GPR15 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR15 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR15. It can be used to detect total GPR15 receptors in Western blots independent of phosphorylation. The GPR15 antibody...
CHF400.00 *
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NEW
Validation of the GPR26 Receptor in transfected HEK293 cells
GPR26 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR26 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR26. It can be used to detect total GPR26 receptors in Western blots independent of phosphorylation. The GPR26 antibody...
CHF400.00 *
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NEW
Validation of the GPR34 Receptor in transfected HEK293 cells
GPR34 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR34 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR34. It can be used to detect total GPR34 receptors in Western blots independent of phosphorylation. The GPR34 antibody...
CHF400.00 *
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Validation of the GPR39 Receptor in transfected HEK293 cells
GPR39 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR39 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR39. It can be used to detect total GPR39 receptors in Western blots independent of phosphorylation. The GPR39 antibody...
CHF400.00 *
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NEW
Validation of the GPR97/ADGR3G Receptor in transfected HEK293 cells
GPR97/ADGRG3 (non-phospho), G protein-coupled...
The non-phospho-GPR97/ADGRG3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR97/ADGRG3. It can be used to detect total GPR97/ADGRG3 receptors in Western blots independent of phosphorylation....
CHF400.00 *
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Validation of the GPR101 Receptor in transfected HEK293 cells
GPR101 (non-phospho), G protein-coupled...
The non-phospho-GPR101 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR101. It can be used to detect total GPR101 receptors in Western blots independent of phosphorylation. The GPR101...
CHF400.00 *
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NEW
Validation of the GPR31 Receptor in transfected HEK293 cells
GPR31 (non-phospho), G protein-coupled...
The non-phospho-GPR31 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR31. It can be used to detect total GPR3 receptors in Western blots independent of phosphorylation. The GPR31 antibody...
CHF400.00 *
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NEW
Validation of the GPR52 Receptor in transfected HEK293 cells
GPR52 (non-phospho), G protein-coupled...
The non-phospho-GPR52 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR52. It can be used to detect total GPR52 receptors in Western blots independent of phosphorylation. The GPR52 antibody...
CHF400.00 *
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Validation of the GPR158/mGlyR Receptor in transfected HEK293 cells
GPR158/mGlyR (non-phospho), G protein-coupled...
The non-phospho-GPR158/mGlyR receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR158/mGlyR. It can be used to detect total GPR158/mGlyR receptors in Western blots independent of phosphorylation....
CHF400.00 *
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Validation of the GPR176 Receptor in transfected HEK293 cells.
GPR176 (non-phospho), G protein-coupled...
The non-phospho-GPR176 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR176. It can be used to detect total GPR176 receptors in Western blots independent of phosphorylation. The GPR176...
CHF400.00 *
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Serine358/Seine362 phosphorylation of the G-protein coupled Receptor 176.
pS358/pS362-GPR176 (phospho-GPR176 Antibody)
Serine358/Serine362 (S358/S362) is a major phosphorylation site of the human GPR176 receptor. The pS358/pS362-GPR176 antibody detects GRK-mediated constitutive phosphorylation as well as PKC-mediated phosphorylation of GPR176 when...
CHF400.00 *
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Threonine427/Serine429 phosphorylation of the G-protein coupled Receptor 75.
pT427/pS429-GPR75 (phospho-GPR75 Antibody)
Threonine427/Serine429 (T427/S429) is a major phosphorylation site of the human GPR75 receptor. The pT427/pS429-GPR75 antibody detects GRK-mediated constitutive phosphorylation of GPR75 when expressed in HEK293 cells.
CHF400.00 *
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Serine422/Serine423 phosphorylation of the G-protein coupled Receptor 75
pS422/pS423-GPR75 (phospho-GPR75 Antibody)
Serine422/Serine423 (S422/S423) is a major phosphorylation site of the human GPR75 receptor. The pS422/pS423-GPR75 antibody detects GRK-mediated constitutive phosphorylation as well as PKC-mediated phosphorylation of GPR75 when expressed...
CHF400.00 *
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Validation of the G protein-coupled Receptor 84 in transfected HEK293 cells
GPR84 (non-phospho), G Protein-Coupled Receptor...
The GPR84 antibody is directed against the distal end of the carboxyl-terminal tail of human GRP84. It can be used to detect total GPR84 receptors in Western blots independent of phosphorylation. The GPR84 antibody can also be used to...
CHF400.00 *
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For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

For more information on orphan receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE,... read more »
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Orphan Receptor Antibodies

For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

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