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GPR97/ADGRG3 Adhesion Receptor Antibodies

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Validation of the GPR97/ADGR3G Receptor in transfected HEK293 cells
GPR97/ADGRG3 (non-phospho), G protein-coupled...
The non-phospho-GPR97/ADGRG3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR97/ADGRG3. It can be used to detect total GPR97/ADGRG3 receptors in Western blots independent of phosphorylation....
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GPR97 (also known as ADGRG3) is a member of the adhesion GPCR family, characterized by a long extracellular domain involved in cell–cell and cell–matrix interactions. While its endogenous ligand remains unclear, GPR97 has been implicated in immune regulation and vascular biology. GPR97 is predominantly expressed in immune cells, including neutrophils, B cells, and dendritic cells, as well as in endothelial cells and some lymphoid tissues. Its expression pattern suggests a role in immune cell activation, inflammatory signaling, and vascular function. GPR97 is being explored as a potential pharmacological target, particularly in immune-related diseases and inflammatory conditions. Preclinical studies have shown that it can influence innate immune responses and may be involved in conditions such as autoimmunity and cancer.  For more information on GPR97/ADGRG3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

GPR97 (also known as ADGRG3) is a member of the adhesion GPCR family, characterized by a long extracellular domain involved in cell–cell and cell–matrix interactions. While its endogenous ligand... read more »
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GPR97/ADGRG3 Adhesion Receptor Antibodies

GPR97 (also known as ADGRG3) is a member of the adhesion GPCR family, characterized by a long extracellular domain involved in cell–cell and cell–matrix interactions. While its endogenous ligand remains unclear, GPR97 has been implicated in immune regulation and vascular biology. GPR97 is predominantly expressed in immune cells, including neutrophils, B cells, and dendritic cells, as well as in endothelial cells and some lymphoid tissues. Its expression pattern suggests a role in immune cell activation, inflammatory signaling, and vascular function. GPR97 is being explored as a potential pharmacological target, particularly in immune-related diseases and inflammatory conditions. Preclinical studies have shown that it can influence innate immune responses and may be involved in conditions such as autoimmunity and cancer.  For more information on GPR97/ADGRG3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

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