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Orphan Receptor Antibodies

The sequencing of the human genome has allowed NC-IUPHAR to catalog all of the human gene sequences potentially encoding GPCRs, excluding sensory receptors. In addition to established transmitter systems, the classification in the Guide to PHARMACOLOGY also includes ‘orphan’ GPCRs where the endogenous ligand(s) is not known. Considerable progress has been made in screening artificially expressed receptors to identify the cognate endogenous ligand.

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Validation of the MRGPRX2 Receptor in transfected HEK293 cells
MRGPRX2 (non-phospho), MRGPRX2 Mas-related...
The non-phospho-MRGPRX2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human MRGPRX2. It can be used to detect total MRGPRX2 receptors in Western blots independent of phosphorylation. The MRGPRX2...
CHF400.00 *
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Validation of the GPR82 Receptor in transfected HEK293 cells
GPR82 (non-phospho), G protein-coupled...
The non-phospho-GPR82 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR82. It can be used to detect total GPR82 receptors in Western blots independent of phosphorylation. The GPR82 antibody...
CHF400.00 *
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Validation of the GPR65 Receptor in transfected HEK293 cells
GPR65 (non-phospho), G protein-coupled...
The non-phospho-GPR65 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR65. It can be used to detect total GPR65 receptors in Western blots independent of phosphorylation. The GPR65 antibody...
CHF400.00 *
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Validation of the GPR61 Receptor in transfected HEK293 cells
GPR61 (non-phospho), G protein-coupled...
The non-phospho-GPR61 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR61. It can be used to detect total GPR61 receptors in Western blots independent of phosphorylation. The GPR61 antibody...
CHF400.00 *
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Validation of the GPR3 Receptor in transfected HEK293 cells
GPR3 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR3. It can be used to detect total GPR3 receptors in Western blots independent of phosphorylation. The GPR3 antibody can...
CHF400.00 *
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Validation of the G Protein-coupled Receptor 17 in transfected HEK293 cells
GPR17 (non-phospho), G Protein-coupled Receptor...
The non-phospho-GPR17 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human GPR17. It can be used to detect total GPR17 receptors in Western blots independent of phosphorylation. The...
CHF400.00 *
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Validation of the GPR183 Receptor in transfected HEK293 cells
GPR183 (non-phospho), Oxysterol Receptor Antibody
The non-phospho-GPR183 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR183. It also detects GPR183 in cultured cells and tissue sections by immunohistochemistry. It can be used to detect...
CHF400.00 *
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Validation of the G protein-coupled receptor 32 in transfected HEK293 cells
GPR32 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR32 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR32. It can be used to detect total GPR32 receptors in Western blots independent of phosphorylation. The GPR32 antibody...
CHF400.00 *
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Validation of the GPR27 Receptor in transfected HEK293 cells
GPR27 (non-phospho), G protein-coupled...
The non-phospho-GPR27 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR27. It can be used to detect total GPR27 receptors in Western blots independent of phosphorylation. The GPR27 antibody...
CHF400.00 *
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Validation of the GPR12 Receptor in transfected HEK293 cells
GPR12 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR12 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR12. It can be used to detect total GPR12 receptors in Western blots independent of phosphorylation. The GPR12 antibody...
CHF400.00 *
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Validation of the GPR6 Receptor in transfected HEK293 cells.
GPR6 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR6 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR6. It can be used to detect total GPR6 receptors in Western blots independent of phosphorylation. The GPR6 antibody can...
CHF400.00 *
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Validation of the GPR25 Receptor in transfected HEK293 cells
GPR25 (non-phospho), G protein-coupled...
The non-phospho-GPR25 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR25. It can be used to detect total GPR25 receptors in Western blots independent of phosphorylation. The GPR25 antibody...
CHF400.00 *
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Validation of the GPR22 Receptor in transfected HEK293 cells
GPR22 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR22 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR22. It can be used to detect total GPR22 receptors in Western blots independent of phosphorylation. The GPR22 antibody...
CHF400.00 *
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Immunohistochemical identification of GPR35 Receptor in human colon
GPR35 (IHC-grade), GPR35 Receptor Antibody
The GPR35 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human GPR35. It can be used to detect total GPR35 receptors in Western blots independent of phosphorylation. The GPR35 antibody can also be...
CHF400.00 *
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Immunohistochemical identification of GPR158/mGlyR Receptor in small intestine
GPR158/mGlyR (IHC-grade), Glycin Receptor...
The non-phospho-GPR158 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR158. It also detects GPR158 in cultured cells and tissue sections by immunohistochemistry. It can be used to detect...
CHF400.00 *
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GPR62 (non-phospho), G protein-coupled Receptor 62 Antibody
GPR62 (non-phospho), G protein-coupled...
The non-phospho-GPR62 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR62. It can be used to detect total GPR62 receptors in Western blots independent of phosphorylation. The GPR62 antibody...
CHF400.00 *
Details
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For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

For more information on orphan receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE,... read more »
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Orphan Receptor Antibodies

For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

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