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GPR18 Receptor Antibodies

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Validation of the GPR18 Receptor in transfected HEK293 cells
GPR18 (non-phospho), G protein-coupled...
The non-phospho-GPR18 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR18. It can be used to detect total GPR18 receptors in Western blots independent of phosphorylation. The GPR18 antibody...
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GPR18 (G Protein-Coupled Receptor 18) is an orphan GPCR that is believed to respond to lipid-based ligands, including N-arachidonoyl glycine (NAGly), a metabolite related to endocannabinoids. While its endogenous ligand remains under debate, GPR18 is functionally associated with immune modulation and inflammation. GPR18 is expressed in various tissues, with high levels in immune cells such as T cells, B cells, macrophages, and microglia. It is also found in the spleen, thymus, testis, and certain regions of the central nervous system, including the brainstem and hypothalamus. GPR18 is considered a potential pharmacological target due to its roles in immune regulation, inflammation, pain, and cancer progression. It has been implicated in processes such as immune cell migration, neuroinflammation, and tumor cell survival. For more information on GPR18 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

GPR18 (G Protein-Coupled Receptor 18) is an orphan GPCR that is believed to respond to lipid-based ligands, including N-arachidonoyl glycine (NAGly), a metabolite related to endocannabinoids.... read more »
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GPR18 Receptor Antibodies

GPR18 (G Protein-Coupled Receptor 18) is an orphan GPCR that is believed to respond to lipid-based ligands, including N-arachidonoyl glycine (NAGly), a metabolite related to endocannabinoids. While its endogenous ligand remains under debate, GPR18 is functionally associated with immune modulation and inflammation. GPR18 is expressed in various tissues, with high levels in immune cells such as T cells, B cells, macrophages, and microglia. It is also found in the spleen, thymus, testis, and certain regions of the central nervous system, including the brainstem and hypothalamus. GPR18 is considered a potential pharmacological target due to its roles in immune regulation, inflammation, pain, and cancer progression. It has been implicated in processes such as immune cell migration, neuroinflammation, and tumor cell survival. For more information on GPR18 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

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