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Melanin-Concentrating Hormone Receptor 1 (MCH1) Antibodies

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Immunohistochemical identification of Melanin-Concentrating Hormone Receptor 1 in pancreas
MCH1 (IHC-grade) Melanin-Concentrating Hormone...
The non-phospho MCH1 receptor antibody is directed against the distal end of the carboxyl-terminal tail human MCH1 receptor. It can be used to detect total MCH1 receptors in Western blots independent of phosphorylation. It can also be...
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Validation of the Melanin-Concentrating Hormone Receptor 1 in transfected HEK293 cells
MCH1 (non-phospho) Melanin-Concentrating...
The non-phospho MCH1 receptor antibody is directed against the distal end of the carboxyl-terminal tail human MCH1 receptor. It can be used to detect total MCH1 receptors in Western blots independent of phosphorylation. It can also be...
CHF400.00 *
Details
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Agonist-induced Serine338/Threonine342 phosphorylation of MCH1 Receptor.
pS338/pT342-MCH1 (phospho-Melanin-Concentrating...
Serine338/Threonine342 (S338/T342) is a major phosphorylation site of the MCH1 receptor. The pS338/pT342-MCH1 antibody detects phosphorylation in response to high-efficacy agonists. S338/T342 phosphorylation is a key regulator of MCH1...
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Agonist-induced Threonine348/Serine350 phosphorylation of MCH1 Receptor
pT348/pS350-MCH1 (phospho-Melanin-Concentrating...
Threonine348/Serine350 (T348/S350) is a major phosphorylation site of the MCH1 receptor. The pT348/pS350-MCH1 antibody detects phosphorylation in response to high-efficacy agonists. T348/S350 phosphorylation is a key regulator of MCH1...
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The melanin-concentrating hormone receptor 1 (MCH1) is the receptor for a 19 amino-acids cyclic peptide. The highest expression of MCH1 is found in the brain: frontal cortex, amygdala and nucleus accumbens, but also in the arcuate nucleus and in the ventral medial hypothalamus. MCH1 seems to play a role in appetite regulation and obesity. Knock out mice for MCH1 are leaner, even on high fat diet. Several antagonists at MCH1 showed antidepressant and anxiolytic activities. MCH1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine338/threonine342 (pS338/pT342-MCH1) and threonine348/serine350 (pT348/pS350-MCH1). This nomenclature refers to the human MCH1 receptor but is identical in mice and rats. For more information on MCH1 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Audinot V, Boutin JA, Lakaye B, Nahon JL, Saito Y. Melanin-concentrating hormone receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F37/2023.1.

The melanin-concentrating hormone receptor 1 (MCH1) is the receptor for a 19 amino-acids cyclic peptide. The highest expression of MCH1 is found in the brain: frontal cortex, amygdala and... read more »
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Melanin-Concentrating Hormone Receptor 1 (MCH1) Antibodies

The melanin-concentrating hormone receptor 1 (MCH1) is the receptor for a 19 amino-acids cyclic peptide. The highest expression of MCH1 is found in the brain: frontal cortex, amygdala and nucleus accumbens, but also in the arcuate nucleus and in the ventral medial hypothalamus. MCH1 seems to play a role in appetite regulation and obesity. Knock out mice for MCH1 are leaner, even on high fat diet. Several antagonists at MCH1 showed antidepressant and anxiolytic activities. MCH1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine338/threonine342 (pS338/pT342-MCH1) and threonine348/serine350 (pT348/pS350-MCH1). This nomenclature refers to the human MCH1 receptor but is identical in mice and rats. For more information on MCH1 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Audinot V, Boutin JA, Lakaye B, Nahon JL, Saito Y. Melanin-concentrating hormone receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F37/2023.1.

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