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Complement Peptide Receptor Phosphorylation Assays

Complement peptide receptors are activated by a small peptide fragments called C3a, C5a and C5adesArg (previously called anaphylatoxins) that are produced by the complement cascade. Complement peptides are potent chemoattractants and secretagogues that act on immune and non-immune cells. The physiological effects of complement peptides are mediated by a family of three seven transmembrane receptors (7TMRs) designated as C3a, C5a1 and C5a2. While C3a and C5a1 are classical G protein-coupled receptors (GPCRs), C5a2 appears to be permanently uncoupled from G proteins. However,  both C5a1 and C5a2 are required for full pro-inflammatory responses.

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OD signals in pT342-C5a1 Phosphorylation Assay
pT342-C5a1 Phosphorylation Assay Kit
The pT342-C5a1 Phosphorylation Assay Kit allows determination of C5a1 Phosphorylation in 96-well plates without the need for Western blot analysis.
CHF650.00 *
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OD signals in pS338/pT339-C5a1 Phosphorylation Assay
pS338/pT339-C5a1 Phosphorylation Assay Kit
The pS338/pT339-C5a1 Phosphorylation Assay Kit allows determination of C5a1 Phosphorylation in 96-well plates without the need for Western blot analysis.
CHF650.00 *
Details
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OD signals in pS332/pS334-C5a1 Phosphorylation Assay
pS332/pS334-C5a1 Phosphorylation Assay Kit
The pS332/pS334-C5a1 Phosphorylation Assay Kit allows determination of C5a1 Phosphorylation in 96-well plates without the need for Western blot analysis.
CHF650.00 *
Details
NEW
OD signals in pT324pS327-C5a1 Phosphorylation Assay
pT324/pS327-C5a1 Phosphorylation Assay Kit
The pT324/pS327-C5a1 Phosphorylation Assay Kit allows determination of C5a1 Phosphorylation in 96-well plates without the need for Western blot analysis.
CHF650.00 *
Details

For more information on complement peptide receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Klos A, Wende E, Wareham KJ, Monk PN. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol Rev. 2013 Jan;65(1):500-43. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):466. PubMed PMID: 23383423.

For more information on complement peptide receptor pharmacology please refer to the IUPHAR database. For further reading refer to: Klos A, Wende E, Wareham KJ, Monk PN. International... read more »
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Complement Peptide Receptor Phosphorylation Assays

For more information on complement peptide receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Klos A, Wende E, Wareham KJ, Monk PN. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol Rev. 2013 Jan;65(1):500-43. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):466. PubMed PMID: 23383423.

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