GPR101 Receptor Antibodies

GPR101 (G Protein-Coupled Receptor 101) is an orphan GPCR with no confirmed endogenous ligand and limited functional characterization. It is believed to be constitutively active, likely coupling to Gs proteins to stimulate cAMP production, suggesting a role in neuroendocrine signaling. GPR101 is primarily expressed in the central nervous system, particularly in the pituitary gland and hypothalamus, as well as in other brain regions involved in hormonal regulation and growth control. GPR101 has attracted interest as a potential pharmacological target due to its association with X-linked acrogigantism (XLAG), a rare disorder characterized by early-onset growth hormone excess. Overexpression of GPR101 in pituitary tumors suggests a role in pituitary hormone regulation and tumorigenesis. While no targeted therapies exist yet, GPR101 is a candidate for future drug development in endocrine disorders involving growth hormone dysregulation. For more information on GPR101 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.