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EP3 Receptor Antibodies

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Agonist-induced Serine369/Serine370 phosphorylation of the EP3 Prostanoid Receptor
pS369/pS370-EP3 (phospho-EP3 Prostanoid...
Serine369/Serine370 (S369/S370) is major phosphorylation site of the EP3 Prostanoid Receptor (EP3). The pS369/pS370-EP3 antibody detects phosphorylation in response to agonists. S369/S370 phosphorylation is likely to be involved in...
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Agonist-induced Threonine372/Serine373 phosphorylation of the EP3 Prostanoid Receptor
pT372/pS373-EP3 (phospho-EP3 Prostanoid...
Threonine372/Serine373 (T372/S373) is major phosphorylation site of the EP3 Prostanoid Receptor (EP3). The pT372/pS373-EP3 antibody detects phosphorylation in response to agonists. T372/S373 phosphorylation is likely to be involved in...
CHF400.00 *
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Agonist-induced Serine379/Serine380 phosphorylation of the EP3 Prostanoid Receptor
pS379/pS380-EP3 (phospho-EP3 Prostanoid...
Serine379/Serine380 (S379/S380) is major phosphorylation site of the EP3 Prostanoid Receptor (EP3). The pS379/pS380-EP3 antibody detects phosphorylation in response to agonists. S379/S380 phosphorylation is likely to be involved in...
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Validation of the EP3 Prostanoid Receptor in transfected HEK293 cells
EP3 (non-phospho), EP3 Prostanoid Receptor...
The non-phospho-EP3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human EP3. It can be used to detect total EP3 receptors in Western blots independent of phosphorylation.The EP3 antibody can also...
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EP3 receptors mediate a wide spectrum of  actions: contraction of smooth muscle, enhancement of platelet aggregation, inhibition of autonomic neurotransmitter release, inhibition of gastric acid secretion, and inhibition of fat cell lipolysis. EP3 receptors are subject to splice variance at the C-terminus and, to date, ten isoforms have been identified across species, six of these being expressed in man. These isoforms differ in their G-protein coupling. Several chemical classes of selective EP3 receptor antagonists have emerged. EP3 receptor antagonism has been investigated for inhibition of platelet activation in atherothrombotic disease. EP3 receptors are regulated by phosphorylation of carboxyl-terminal serine369/serine370 (pS369/pS370-EP3), threonine372/serine373 (pT372/pS373-EP3) and serine379/serine380 (pS379/pS380-EP3). This nomenclature refers to the canonical isoform of human EP3 receptor. This phosphorylation motif is highly conserved across species but corresponds to pS344/pS345-EP3, pT347/pS348-EP3 and pS354/pS355-EP3 in mice and rats. For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.

Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.

EP3 receptors mediate a wide spectrum of  actions: contraction of smooth muscle, enhancement of platelet aggregation, inhibition of autonomic neurotransmitter release, inhibition of... read more »
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EP3 Receptor Antibodies

EP3 receptors mediate a wide spectrum of  actions: contraction of smooth muscle, enhancement of platelet aggregation, inhibition of autonomic neurotransmitter release, inhibition of gastric acid secretion, and inhibition of fat cell lipolysis. EP3 receptors are subject to splice variance at the C-terminus and, to date, ten isoforms have been identified across species, six of these being expressed in man. These isoforms differ in their G-protein coupling. Several chemical classes of selective EP3 receptor antagonists have emerged. EP3 receptor antagonism has been investigated for inhibition of platelet activation in atherothrombotic disease. EP3 receptors are regulated by phosphorylation of carboxyl-terminal serine369/serine370 (pS369/pS370-EP3), threonine372/serine373 (pT372/pS373-EP3) and serine379/serine380 (pS379/pS380-EP3). This nomenclature refers to the canonical isoform of human EP3 receptor. This phosphorylation motif is highly conserved across species but corresponds to pS344/pS345-EP3, pT347/pS348-EP3 and pS354/pS355-EP3 in mice and rats. For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.

Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.

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