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GPR3 Receptor Antibodies

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Validation of the GPR3 Receptor in transfected HEK293 cells
GPR3 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR3. It can be used to detect total GPR3 receptors in Western blots independent of phosphorylation. The GPR3 antibody can...
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GPR3 (G Protein-Coupled Receptor 3) is an orphan GPCR that exhibits constitutive activity, meaning it signals in the absence of a known ligand. It primarily activates the Gs protein pathway, leading to increased intracellular cAMP levels. GPR3 plays important roles in neurobiology and reproductive physiology. GPR3 is highly expressed in the central nervous system, particularly in regions such as the hippocampus and cerebellum, as well as in oocytes and granulosa cells of the ovary. In the brain, it has been implicated in processes related to mood regulation, neurogenesis, and neuroprotection. In the ovary, it helps maintain meiotic arrest in oocytes. GPR3 is being explored as a pharmacological target in several areas, notably neurodegenerative diseases such as Alzheimer’s disease, due to its involvement in amyloid-β production and neuronal function. Its constitutive activity and role in oocyte maturation also make it of interest in reproductive biology. For more information on GPR3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

GPR3 (G Protein-Coupled Receptor 3) is an orphan GPCR that exhibits constitutive activity, meaning it signals in the absence of a known ligand. It primarily activates the Gs protein pathway,... read more »
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GPR3 Receptor Antibodies

GPR3 (G Protein-Coupled Receptor 3) is an orphan GPCR that exhibits constitutive activity, meaning it signals in the absence of a known ligand. It primarily activates the Gs protein pathway, leading to increased intracellular cAMP levels. GPR3 plays important roles in neurobiology and reproductive physiology. GPR3 is highly expressed in the central nervous system, particularly in regions such as the hippocampus and cerebellum, as well as in oocytes and granulosa cells of the ovary. In the brain, it has been implicated in processes related to mood regulation, neurogenesis, and neuroprotection. In the ovary, it helps maintain meiotic arrest in oocytes. GPR3 is being explored as a pharmacological target in several areas, notably neurodegenerative diseases such as Alzheimer’s disease, due to its involvement in amyloid-β production and neuronal function. Its constitutive activity and role in oocyte maturation also make it of interest in reproductive biology. For more information on GPR3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

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