CC Chemokine Receptor 1 Antibodies

CCR1 (C-C chemokine receptor type 1) is a G protein-coupled receptor involved in the immune system’s response to inflammation. It binds chemokines such as CCL3 (MIP-1α), CCL5 (RANTES), and CCL7, guiding the migration and activation of immune cells. CCR1 is mainly expressed on immune cells, including monocytes, macrophages, T lymphocytes, neutrophils, and dendritic cells. It is found in blood, lymphoid tissues, and inflamed sites. CCR1 is considered a pharmacological target. It is implicated in various inflammatory and autoimmune conditions, such as rheumatoid arthritis, multiple sclerosis, and transplant rejection. Several CCR1 antagonists have been explored in clinical trials, though none have yet reached routine clinical use. For more information on CCR1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A. International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev. 2013 Nov 11;66(1):1-79. doi: 10.1124/pr.113.007724. Print 2014. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):467. PubMed PMID: 24218476; PubMed Central PMCID: PMC3880466.