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Orphan Receptor Antibodies

The sequencing of the human genome has allowed NC-IUPHAR to catalog all of the human gene sequences potentially encoding GPCRs, excluding sensory receptors. In addition to established transmitter systems, the classification in the Guide to PHARMACOLOGY also includes ‘orphan’ GPCRs where the endogenous ligand(s) is not known. Considerable progress has been made in screening artificially expressed receptors to identify the cognate endogenous ligand.

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Immunohistochemical identification of G Protein-coupled Receptor 84 in lymph node
GPR84 (IHC-grade), G Protein-Coupled Receptor...
The GPR84 antibody is directed against the distal end of the carboxyl-terminal tail of human GRP84. It can be used to detect total GPR84 receptors in Western blots independent of phosphorylation. The GPR84 antibody can also be used to...
CHF400.00 *
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Immunohistochemical identification of G Protein-coupled Receptor 17 in oligodendrocytes
GPR17 (GP-IHC-grade), G Protein-Coupled...
The GPR17 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP17. It can be used to detect total GPR17 receptors in Western blots independent of phosphorylation. The GPR17 antibody can...
CHF400.00 *
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Immunohistochemical identification of G Protein-coupled Receptor 82 in hippocampus
GPR82 (IHC-grade), G Protein-Coupled Receptor...
The GPR82 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP82. It can be used to detect total GPR82 receptors in Western blots independent of phosphorylation. The GPR82 antibody can...
CHF400.00 *
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Immunohistochemical identification of G Protein-coupled Receptor 65 in small intestine
GPR65 (IHC-grade), G Protein-Coupled Receptor...
The GPR65 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP65. It can be used to detect total GPR65 receptors in Western blots independent of phosphorylation. The GPR65 antibody can...
CHF400.00 *
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Immunohistochemical identification of G Protein-coupled Receptor 61 in cortex
GPR61 (IHC-grade), G Protein-Coupled Receptor...
The GPR61 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP61. It can be used to detect total GPR61 receptors in Western blots independent of phosphorylation. The GPR61 antibody can...
CHF400.00 *
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Immunohistochemical identification of GPR3 Receptor in Cortex
GPR3 (IHC-grade), G Protein-Coupled Receptor 3...
The GPR3 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP3. It can be used to detect total GPR3 receptors in Western blots independent of phosphorylation. The GPR3 antibody can also be...
CHF400.00 *
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Agonist-induced Threonine314/Threonine315 phosphorylation of GPR55
pT314/pT315-GPR55 (phospho-GPR55 Antibody)
Threonine314/Threonine315 (T314/T315) is major phosphorylation site of human GPR55 receptor. The pT314/pT315-GPR55 antibody detects phosphorylation in response to agonists. T314/T315) phosphorylation is likely to be involved in efficient...
CHF400.00 *
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NEW
Immunohistochemical identification of G Protein-coupled Receptor 17 in oligodendrocytes.
GPR17 (IHC-grade), G Protein-Coupled Receptor...
The GPR17 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP17. It can be used to detect total GPR17 receptors in Western blots independent of phosphorylation. The GPR17 antibody can...
CHF400.00 *
Details
NEW
Immunohistochemical identification of GPR32 Receptor in Small Intestine
GPR32 (IHC-grade), G Protein-Coupled Receptor...
The GPR32 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP32. It can be used to detect total GPR32 receptors in Western blots independent of phosphorylation. The GPR32 antibody can...
CHF400.00 *
Details
NEW
Immunohistochemical identification of GPR27 Receptor in small intestine
GPR27 (IHC-grade), G Protein-Coupled Receptor...
The GPR27 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP27. It can be used to detect total GPR27 receptors in Western blots independent of phosphorylation. The GPR27 antibody can...
CHF400.00 *
Details
NEW
Immunohistochemical identification of GPR12 Receptor in kidney
GPR12 (IHC-grade), G Protein-Coupled Receptor...
The GPR12 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP12. It can be used to detect total GPR12 receptors in Western blots independent of phosphorylation. The GPR12 antibody can...
CHF400.00 *
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Immunohistochemical identification of GPR6 Receptor in small intestine
GPR6 (IHC-grade), G Protein-Coupled Receptor 6...
The GPR6 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP6. It can be used to detect total GPR6 receptors in Western blots independent of phosphorylation. The GPR6 antibody can also be...
CHF400.00 *
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Immunohistochemical identification of GPR25 Receptor in small intestine
GPR25 (IHC-grade), G Protein-Coupled Receptor...
The GPR25 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP25. It can be used to detect total GPR25 receptors in Western blots independent of phosphorylation. The GPR25 antibody can...
CHF400.00 *
Details
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Immunohistochemical identification of GPR22 Receptor in Pancreas
GPR22 (IHC-grade), G Protein-Coupled Receptor...
The GPR22 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP22. It can be used to detect total GPR22 receptors in Western blots independent of phosphorylation. The GPR22 antibody can...
CHF400.00 *
Details
NEW
Agonist-induced Threoine347/Serine349 phosphorylation of GPR183
pT347/pT349-GPR183 (phospho-GPR183 Antibody)
Threonine347/Threonine349 (T347/T349) is major phosphorylation site of human GPR183 receptor. The pT347/pT349-GPR183 antibody detects phosphorylation in response to agonists. T347/T349 phosphorylation is likely to be involved in...
CHF400.00 *
Details
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KO-Validated
Western blot analysis of G Protein-coupled Receptor 20 in mouse tissues in vivo.
mGPR20 (non-phospho-G Protein-Coupled Receptor...
The GPR20 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse GPR20. It can be used to detect total GPR20 receptors in Western blots independent of phosphorylation. The GPR20 antibody can also be...
CHF400.00 *
Details
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For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

For more information on orphan receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE,... read more »
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Orphan Receptor Antibodies

For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

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