Melanin-Concentrating Hormone Receptor 2 (MCH2) Antibodies

MCH2 (Melanin-Concentrating Hormone Receptor 2) is a G protein-coupled receptor that binds melanin-concentrating hormone (MCH), a neuropeptide involved in regulating energy balance, mood, and feeding behavior. MCH2 is one of two known MCH receptors (MCH1R and MCH2R), but unlike MCH1R, which is widely expressed in humans and rodents, MCH2R is not present in rodents and is primarily found in humans and some other primates. MCH2 is expressed in several human tissues, including the brain, particularly in regions involved in emotion and energy homeostasis, as well as in peripheral tissues such as the gastrointestinal tract and reproductive organs. Its distribution suggests a role in modulating both central and peripheral physiological functions. MCH2 is considered a potential pharmacological target, particularly for disorders related to mood, anxiety, and metabolic regulation, such as obesity and depression. MCH2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine335/serine338 (pT335/pS338-MCH2). This nomenclature refers to the human MCH2 receptor. For more information on MCH2 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Audinot V, Boutin JA, Lakaye B, Nahon JL, Saito Y. Melanin-concentrating hormone receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F37/2023.1.