CB2 (GP-IHC-grade) Cannabinoid Receptor 2 Antibody, Guinea Pig

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CB2 (GP-IHC-grade) Cannabinoid Receptor 2 Antibody, Guinea Pig

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Order number: 7TM0057N-ICGP
Content: 100 µl
Host: Rabbit

The non-phospho-CB2 receptor antibody is directed against the distal end of the... more

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The non-phospho-CB2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human CB2. It can be used to detect total CB2 receptors in Western blots independent of phosphorylation. The CB2 antibody can also be used to isolate and enrich CB2 receptors from tissue lysates. It also detects CB2 in cultured cells and tissue sections by immunohistochemistry.

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Alternative Names CB-R, Central Cannabinoid Receptor IUPHAR Target... more

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Alternative Names	CB-R, Central Cannabinoid Receptor
IUPHAR Target ID	56
UniProt ID	P21554
Western Blot (WB)	1:1000
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human CB1 around the phosphorylation site of Ser425.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine425 phosphorylation of the Cannabinoid Receptor 1. Upper... more

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Figure 1. Agonist-induced Serine425 phosphorylation of the Cannabinoid Receptor 1. Upper panel, HEK293 cells stably expressing the CB1-Receptor (CB1) were either not exposed or exposed to 10 µM of CB1-Receptor agonists CP55940 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS425-CB1 antibody (7TM0056A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CB1 antibody to confirm equal loading of the gel.

Fritzwanker S, Nagel F, Kliewer A, Stammer V, Schulz S. In situ visualization of opioid and... more

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Fritzwanker S, Nagel F, Kliewer A, Stammer V, Schulz S. In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies. Commun Biol. 2023 Apr 15;6(1):419. doi: 10.1038/s42003-023-04786-2. PMID: 37061609; PMCID: PMC10105690.

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