Premium Phosphosite-Specific 7TM Antibodies
Your Resource for GPCR Research
Select Your Country of Delivery below

Secretin Receptor Antibodies

Close filters
No results were found for the filter!
NEW
SCTR (non-phospho) Scretin Receptor Antibody
SCTR (non-phospho) Scretin Receptor Antibody
The non-phospho SCTR receptor antibody is directed against the distal end of the carboxyl-terminal tail human SCTR receptor. It can be used to detect total SCTR receptors in Western blots independent of phosphorylation. It can also be...
CHF400.00 *
Details

The secretin receptor (SCTR) is a class B G protein-coupled receptor that mediates the physiological actions of the peptide hormone secretin, primarily in the gastrointestinal tract and pancreas. Pharmacologically, SCTR is activated by endogenous secretin and has been explored as a potential target in disorders of pancreatic secretion, cholestasis, and certain metabolic or gastrointestinal diseases, although no widely used SCTR-selective therapeutic drugs are currently approved. Upon ligand binding, the receptor predominantly couples to Gs proteins, stimulating adenylate cyclase, elevating intracellular cyclic AMP levels, and activating protein kinase A–dependent signaling pathways. These signaling events promote bicarbonate-rich fluid secretion from pancreatic and biliary ductal cells and contribute to regulation of gastric acid balance and intestinal function. Additional downstream mechanisms, including MAP kinase and calcium-dependent pathways, may modulate cellular proliferation, differentiation, and protective responses in epithelial tissues. SCTR expression is highest in pancreatic ductal cells, cholangiocytes, and specific regions of the stomach and intestine, with additional expression reported in the brain and other peripheral tissues. This distribution reflects the receptor’s central role in coordinating digestive secretions, mucosal protection, and broader neuroendocrine regulation. For more information on SCTR pharmacology please refer to the IUPHAR database. For further reading refer to:

Mayo KE, Miller LJ, Bataille D, Dalle S, Göke B, Thorens B, Drucker DJ. International Union of Pharmacology. XXXV. The glucagon receptor family. Pharmacol Rev. 2003 Mar;55(1):167-94. doi: 10.1124/pr.55.1.6. PMID: 12615957.

Bataille D, Chan SL, Delagrange P, Drucker DJ, Göke B, Hills R, Mayo KE, Miller LJ, Salvatori R, Thorens B. Glucagon receptor family in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

The secretin receptor (SCTR) is a class B G protein-coupled receptor that mediates the physiological actions of the peptide hormone secretin, primarily in the gastrointestinal tract and pancreas.... read more »
Close window
Secretin Receptor Antibodies

The secretin receptor (SCTR) is a class B G protein-coupled receptor that mediates the physiological actions of the peptide hormone secretin, primarily in the gastrointestinal tract and pancreas. Pharmacologically, SCTR is activated by endogenous secretin and has been explored as a potential target in disorders of pancreatic secretion, cholestasis, and certain metabolic or gastrointestinal diseases, although no widely used SCTR-selective therapeutic drugs are currently approved. Upon ligand binding, the receptor predominantly couples to Gs proteins, stimulating adenylate cyclase, elevating intracellular cyclic AMP levels, and activating protein kinase A–dependent signaling pathways. These signaling events promote bicarbonate-rich fluid secretion from pancreatic and biliary ductal cells and contribute to regulation of gastric acid balance and intestinal function. Additional downstream mechanisms, including MAP kinase and calcium-dependent pathways, may modulate cellular proliferation, differentiation, and protective responses in epithelial tissues. SCTR expression is highest in pancreatic ductal cells, cholangiocytes, and specific regions of the stomach and intestine, with additional expression reported in the brain and other peripheral tissues. This distribution reflects the receptor’s central role in coordinating digestive secretions, mucosal protection, and broader neuroendocrine regulation. For more information on SCTR pharmacology please refer to the IUPHAR database. For further reading refer to:

Mayo KE, Miller LJ, Bataille D, Dalle S, Göke B, Thorens B, Drucker DJ. International Union of Pharmacology. XXXV. The glucagon receptor family. Pharmacol Rev. 2003 Mar;55(1):167-94. doi: 10.1124/pr.55.1.6. PMID: 12615957.

Bataille D, Chan SL, Delagrange P, Drucker DJ, Göke B, Hills R, Mayo KE, Miller LJ, Salvatori R, Thorens B. Glucagon receptor family in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

Recently viewed