CXC Chemokine Receptor 1 Antibodies

C-X-C chemokine receptor 1 (CXCR1), encoded by CXCR1, is a class A G protein-coupled receptor activated primarily by CXCL8 (interleukin-8) and also by CXCL6. It couples predominantly to Gi/o, activating pathways that regulate intracellular calcium mobilization, cell adhesion, and chemotaxis. CXCR1 is highly expressed on neutrophils and is also found on other immune cell populations and some tumor cells. In neutrophils, receptor activation promotes migration, degranulation, and reactive oxygen species production, supporting antimicrobial defense. Excessive CXCR1 signaling can contribute to inflammatory tissue injury. Agonist exposure induces receptor phosphorylation, β-arrestin recruitment, and internalization, with subsequent recycling helping restore chemokine responsiveness. The allosteric inhibitors reparixin and ladarixin, which inhibit CXCR1 and CXCR2, have undergone clinical testing in inflammatory diseases and other indications. No CXCR1-selective drug is currently approved for therapeutic use. For more information on CXCR1 pharmacology please refer to the IUPHAR database. For further reading refer to:

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