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Orphan Receptor Antibodies

The sequencing of the human genome has allowed NC-IUPHAR to catalog all of the human gene sequences potentially encoding GPCRs, excluding sensory receptors. In addition to established transmitter systems, the classification in the Guide to PHARMACOLOGY also includes ‘orphan’ GPCRs where the endogenous ligand(s) is not known. Considerable progress has been made in screening artificially expressed receptors to identify the cognate endogenous ligand.

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Validation of the GPR139 Receptor in transfected HEK293 cells
GPR139 (non-phospho), G protein-coupled...
The non-phospho-GPR139 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR139. It can be used to detect total GPR139 receptors in Western blots independent of phosphorylation. The GPR139...
CHF400.00 *
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NEW
Immunohistochemical identification of MRGPRX2 Receptor in small intestine
MRGPRX2 (IHC-grade), MRGPRX2 Mas-related...
The non-phospho-MRGPRX2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human MRGPRX2. It can be used to detect total MRGPRX2 receptors in Western blots independent of phosphorylation. The MRGPRX2...
CHF400.00 *
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NEW
Validation of the GPR146 Receptor in transfected HEK293 cells
GPR146 (non-phospho), G protein-coupled...
The non-phospho-GPR146 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR146. It can be used to detect total GPR146 receptors in Western blots independent of phosphorylation. The GPR146...
CHF400.00 *
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NEW
Validation of the GPR55 Receptor in transfected HEK293 cells
GPR55 (non-phospho), G protein-coupled...
The non-phospho-GPR55 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR55. It can be used to detect total GPR55 receptors in Western blots independent of phosphorylation. The GPR55 antibody...
CHF400.00 *
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NEW
Indentification of GPR183 Receptor in mouse tissues
GPR183 (GP-non-phospho), Oxysterol Receptor...
The non-phospho-GPR183 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR183. It also detects GPR183 in cultured cells and tissue sections by immunohistochemistry. It can be used to detect...
CHF400.00 *
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NEW
Indentification of SUCNR1 Receptor in mouse tissues
SUCNR1/GPR91 (GP-non-phospho), Succinate...
The non-phospho-SUCNR1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human SUCNR1. It can be used to detect total SUCNR1 receptors in Western blots independent of phosphorylation. The SUCNR1...
CHF400.00 *
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Immunohistochemical identification of Serine351/Threonine356 phosphorylation of G-protein coupled Receptor 17 in oligodendrocytes
pS351/pT356-GPR17 (IHC-Grade phospho-GPR17...
Serine351/Threonine356 (S351/T356) is a major phosphorylation site of the human GPR17 receptor. The pS351/pT356-GPR17 antibody detects phosphorylation in response to high-efficacy agonists. S351/T356 phosphorylation is a key regulator of...
CHF600.00 *
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NEW
Validation of the GPR12 Receptor in transfected HEK293 cells
GPR12 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR12 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR12. It can be used to detect total GPR12 receptors in Western blots independent of phosphorylation. The GPR12 antibody...
CHF400.00 *
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NEW
Validation of the GPR6 Receptor in transfected HEK293 cells.
GPR6 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR6 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR6. It can be used to detect total GPR6 receptors in Western blots independent of phosphorylation. The GPR6 antibody can...
CHF400.00 *
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NEW
Validation of the GPR3 Receptor in transfected HEK293 cells
GPR3 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR3. It can be used to detect total GPR3 receptors in Western blots independent of phosphorylation. The GPR3 antibody can...
CHF400.00 *
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NEW
Immunohistochemical identification of GPR183 Receptor in human spleen
GPR183 (IHC-grade), Oxysterol Receptor Antibody
The non-phospho-GPR183 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR183. It also detects GPR183 in cultured cells and tissue sections by immunohistochemistry. It can be used to detect...
CHF400.00 *
Details
NEW
Validation of the GPR119 Receptor in transfected HEK293 cells
GPR119 (non-phospho), G protein-coupled...
The non-phospho-GPR119 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR119. It can be used to detect total GPR119 receptors in Western blots independent of phosphorylation. The GPR119...
CHF400.00 *
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NEW
Validation of the GPR62 Receptor in transfected HEK293 cells
GPR62 (non-phospho), G protein-coupled...
The non-phospho-GPR62 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR62. It can be used to detect total GPR62 receptors in Western blots independent of phosphorylation. The GPR62 antibody...
CHF400.00 *
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NEW
Validation of the GPR97/ADGR3G Receptor in transfected HEK293 cells
ADGRG3/GPR97 (non-phospho), Adhesion Receptor...
The non-phospho-ADGRG3/GPR97 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human ADGRG3/GPR97. It can be used to detect total ADGRG3/GPR97 receptors in Western blots independent of phosphorylation....
CHF400.00 *
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NEW
Agonist-induced Serine300/Serine303 phosphorylation of GPR35 Receptor.
pS300/pS303-hGPR35 (phospho-human GPR35 Antibody)
Serine300/Serine303 (S300/S303) is a major phosphorylation site of the human GPR35 receptor. The pS300/pS303-hGPR35 antibody detects phosphorylation in response to high-efficacy agonists. S300/S303 phosphorylation is a key regulator of...
CHF400.00 *
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Agonist-induced Serine298/Serine301 phosphorylation of mouse GPR35 Receptor
pS298/pS301-mGPR35 (phospho-mouse GPR35 Antibody)
Serine298/Serine301 (S298/S301) is a major phosphorylation site of the mouse GPR35 receptor. The pS298/pS301-mGPR35 antibody detects phosphorylation in response to high-efficacy agonists. S298/S301 phosphorylation is a key regulator of...
CHF400.00 *
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For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

For more information on orphan receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE,... read more »
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Orphan Receptor Antibodies

For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

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