Premium Phosphosite-Specific 7TM Antibodies
Novel Tools for Your GPCR Research
Select Your Country of Delivery below

Immuno-Grade GPR22 Receptor Antibodies

Close filters
No results were found for the filter!
NEW
Immunohistochemical identification of GPR22 Receptor in Pancreas
GPR22 (IHC-grade), G Protein-Coupled Receptor...
The GPR22 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human GRP22. It can be used to detect total GPR22 receptors in Western blots independent of phosphorylation. The GPR22 antibody can...
CHF400.00 *
Details

GPR22 (G Protein-Coupled Receptor 22) is an orphan GPCR with constitutive activity, primarily coupling to Gi/o proteins, which leads to decreased intracellular cAMP levels. Its endogenous ligand has not been identified, and its physiological functions are still being elucidated. GPR22 is mainly expressed in the heart, particularly in cardiomyocytes, as well as in the brain, including the cerebellum and hippocampus. Its expression in cardiac tissue suggests a role in cardiac function and remodeling, especially in response to stress or injury. GPR22 is under investigation as a potential pharmacological target in cardiovascular disease, particularly for its possible involvement in cardiac protection, hypertrophy, and heart failure. For more information on GPR22 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

GPR22 (G Protein-Coupled Receptor 22) is an orphan GPCR with constitutive activity, primarily coupling to Gi/o proteins, which leads to decreased intracellular cAMP levels. Its endogenous ligand... read more »
Close window
Immuno-Grade GPR22 Receptor Antibodies

GPR22 (G Protein-Coupled Receptor 22) is an orphan GPCR with constitutive activity, primarily coupling to Gi/o proteins, which leads to decreased intracellular cAMP levels. Its endogenous ligand has not been identified, and its physiological functions are still being elucidated. GPR22 is mainly expressed in the heart, particularly in cardiomyocytes, as well as in the brain, including the cerebellum and hippocampus. Its expression in cardiac tissue suggests a role in cardiac function and remodeling, especially in response to stress or injury. GPR22 is under investigation as a potential pharmacological target in cardiovascular disease, particularly for its possible involvement in cardiac protection, hypertrophy, and heart failure. For more information on GPR22 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

Recently viewed